Cellular Injury

This is now the first 2 topic on the Pathology MCQ matrix at 3 MCQs cellular injury (5 further MCQs for tissue injury)
Syllabus now says:
        1.1 Cellular adaptation 1
        1.2 Mechanism of cell injury 1
i.e. The College has removed the "Normal Cell" that used to be the first part of the Pathology syllabus.

I still feel that understanding Physiology "building block" concepts and the  "Principles of cellular function" before tackling cellular level pathology is important but they are now only found in the Physiology Syllabus.


Pathology Unit 2:

• Free radical and chemically-induced injury.

• Definition of apoptosis.

• Morphological changes in apoptosis.

• Intracellular accumulations.

• Fatty change.

• Pigments.

• Calcification:- Types & examples (Popular viva & MCQ)

Amit says:

  • Definitions of hypertrophy, hyperplasia, atrophy, metaplasia, dysplasia,

  • Describe mechanisms of cell inj. and death

  • Describe morphology of reversible and irreversible injury

  • What is apoptosis, and describe its mechanism, and morphology

  • Describe different types of necrosis, with examples, and morphology

  • What is the mechanism of reperfusion injury


This is a classic "Question 1" for the path component of the exam...

2011-1-3-1    Cell death/necrosis
2011-1-2-1    Atrophy
2011-1-1-1    Ischaemic cell injury
2010-2-2-1    Hypertrophy
2010-1-3-1    Hypertrophy
2010-1-2-1    Metaplasia
2010-1-1-1    Reperfusion injury
2009-2-3-1    Reversible versus irreversible cellular injury
2009-1-2-1    Cellular changes following ischemia
2008-2-1-1    Ischemic injury
2008-1-2-1    Apoptosis
2008-1-1-1    Hypertrophy vs. Hyperplasia
2007-2-1-1    Metaplasia
2007-1-3-1    Hypertrophy
2007-1-2-1    Atrophy
2007-1-1-1    Hyperplasia
2006-2-3-1    Apoptosis
2006-2-2-1    Reperfusion injury
2006-1-2-1    Reversible vs. irreversible ischaemic change
2006-1-1-1    Reperfusion injury

Robbins says:

Chapter 2 – Cellular Responses to Stress and Toxic Insults  : Adaptation, Injury, and Death

consider aiding your reading with the read-along Robbins version on youtube:
There is also a series of lectures online: